Title: Effects of Probenecid on the Pharmacokinetics of the Neuraminidase Inhibitor Oseltamivir
نویسندگان
چکیده
Methods: Data from a total of 96 subjects, who received various dosages of oral and i.v. oseltamivir either in singleor repeated-dose regimens in four separate studies, and for whom rich PK data was available, were used for the development of the oseltamivir population PK model. Single dose data from 19 subjects in a fifth study, which included an OP arm and an OP + probenecid arm, were used to analyze the effect of probenecid coadministration on the PK of oseltamivir. Model development was performed using non-linear mixed-effect modeling within the program NONMEM (version VI, Level 1.0). All oseltamivir PK data were log-transformed and either the FO or the FOCE method was used for parameter estimation.
منابع مشابه
Pharmacokinetics and tolerability of oseltamivir combined with probenecid.
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